Figure 1

Human Hyal2 protein features. Amino acids 1–20 constitute the endoplasmic reticulum signal peptide for human Hyal2 [3]. A glycosylphosphatidylinositol (GPI) anchor is predicted to replace all residues following amino acid 447 in human Hyal2, which contains a C-terminal hydrophobic tail at residues 456–473 that localizes the protein in the membrane prior to GPI anchor addition.