Table 1 SOM and K-means Analysis of Tat-upregulated genes at the G1/S phase.a
From: Therapeutic targets for HIV-1 infection in the host proteome
Gene Ontology | Accession # | Gene Title | Gene Symbol | Unigene ID |
|---|---|---|---|---|
Transcription/ | D83782 | SREBP cleavage-activating protein | SCAP | Hs.437096 |
DNA binding | AC004770 | fatty acid desaturase 3 | FADS3 | Hs.21765 |
Enzymes | Y08685 | serine palmitoyltransferase, long chain base subunit 1 | SPTLC1 | Hs.90458 |
| Â | D50840 | UDP-glucose ceramide glucosyltransferase | UGCG | Hs.432605 |
| Â | AF038961 | mannose-P-dolichol utilization defect 1 | MPDU1 | Hs.95582 |
| Â | U67368 | exostoses (multiple) 2 | EXT2 | Hs.75334 |
| Â | M22488 | bone morphogenetic protein 1 | BMP1 | Hs.1274 |
| Â | AF002668 | degenerative spermatocyte homolog, lipid desaturase (Drosophila) | DEGS | Hs.299878 |
| Â | AB016247 | sterol-C5-desaturase-like | SC5DL | Hs.287749 |
| Â | X15525 | acid phosphatase 2, lysosomal | ACP2 | Hs.75589 |
| Â | D13643 | 24-dehydrocholesterol reductase | DHCR24 | Hs.75616 |
| Â | AF020543 | palmitoyl-protein thioesterase 2 | PPT2 | Hs.332138 |
| Â | AL050118 | fatty acid desaturase 2 | FADS2 | Hs.388164 |
| Â | M16424 | beta-hexosaminidase A (alpha polypeptide) | HEXA | Hs.411157 |
| Â | L13972 | sialyltransferase 4A (beta-galactoside alpha-2,3-sialyltransferase) | SIAT4A | Hs.356036 |
Membrane/ | D79206 | syndecan 4 (amphiglycan, ryudocan) | SDC4 | Hs.252189 |
Antigens | M90683 | HLA-G histocompatibility antigen, class I, G | HLA-G | Hs.512152 |
| Â | X58536 | major histocompatibility complex, class I, C & B | HLA-C, B | Hs.77961 |
| Â | AF068227 | ceroid-lipofuscinosis, neuronal 5 | CLN5 | Hs.30213 |
| Â | U72515 | putative protein similar to nessy (Drosophila) | C3F | Hs.530552 |
| Â | X85116 | stomatin | STOM | Hs.439776 |
| Â | Z26317 | desmoglein 2 | DSG2 | Hs.412597 |
| Â | S90469 | P450 (cytochrome) oxidoreductase | POR | Hs.354056 |
Receptors/Ligands | U97519 | podocalyxin-like | PODXL | Hs.16426 |
| Â | AI263885 | interleukin 27 receptor, alpha | IL27RA | Hs.132781 |
| Â | U60805 | oncostatin M receptor | OSMR | Hs.238648 |
| Â | M63959 | low density lipoprotein receptor-related protein associated protein 1 | LRPAP1 | Hs.75140 |
| Â | L25931 | lamin B receptor | LBR | Hs.435166 |
| Â | X00588 | epidermal growth factor receptor | EGFR | Hs.77432 |
| Â | M25915 | clusterin | CLU | Hs.436657 |
| Â | X87949 | heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa) | HSPA5 | Hs.310769 |
Proteases | AF032906 | cathepsin Z | CTSZ | Hs.252549 |
| Â | AB001928 | cathepsin L2 | CTSL2 | Hs.87417 |
| Â | Y00264 | Amyloid beta (A4) precursor protein | APP | Hs.177486 |
Protein transport/Chaperone | D83174 | serine (or cysteine) proteinase inhibitor, clade H, member 1 | SERPINH1 | Hs.241579 |
| Â | Z49835 | glucose regulated protein, 58 kDa | GRP58 | Hs.110029 |
| Â | X97335 | A kinase (PRKA) anchor protein 1 | AKAP1 | Hs.78921 |
| Â | X90872 | gp25L2 protein | HSGP25L2G | Hs.279929 |
| Â | D49489 | thioredoxin domain containing 7 (protein disulfide isomerase) | TXNDC7 | Hs.212102 |
| Â | AF013759 | calumenin | CALU | Hs.7753 |
| Â | AL008726 | protective protein for beta-galactosidase (galactosialidosis) | PPGB | Hs.118126 |
| Â | Z50022 | pituitary tumor-transforming 1 interacting protein | PTTG1IP | Hs.369026 |
| Â | AA487755 | FK506 binding protein 9, 63 kDa | FKBP9 | Hs.497972 |
Ion channel/transporter | U81800 | solute carrier family 16, member 3 | SLC16A3 | Hs.386678 |
| Â | M23114 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | ATP2A2 | Hs.374535 |
| Â | J04027 | ATPase, Ca++ transporting, plasma membrane 1 | ATP2B1 | Hs.20952 |
| Â | AL049929 | ATPase, H+ transporting, lysosomal accessory protein 2 | ATP6AP2 | Hs.183434 |
| Â | AL096737 | solute carrier family 5, member 6 | SLC5A6 | Hs.435735 |
Unknown/Other | AF052159 | protein tyrosine phosphatase-like, member b | PTPLB | Hs.5957 |
| Â | D14658 | KIAA0102 gene product | KIAA0102 | Hs.87095 |
| Â | AI867349 | nicastrin-like protein | NICALIN | Hs.24983 |
| Â | AL031228 | solute carrier family 39 (zinc transporter), member 7 | SLC39A7 | Hs.66776 |
| Â | X57398 | nodal modulator 1, 2, 3 | NOMO1, 2, 3 | Hs.429975 |