Figure 5
From: Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS
HIV-1 SF162 infection of human microglia induces rapid ASC intracellular translocation. A. Mock-infected microglia exhibit minimal ASC immunoreactivity. B. At 1Â hr post-infection ASC immunoreactivity (red) was detected in the cytoplasm. C. At 2Â hr post-infection, punctate ASC immunoreactivity was evident in the cytoplasm of microglia. D. At 3Â hr post-infection, aggregates of ASC immunoreactivity was readily apparent in microglia. (Original magnification 400X).