Skip to main content
Figure 8 | Retrovirology

Figure 8

From: Live attenuated rubella vectors expressing SIV and HIV vaccine antigens replicate and elicit durable immune responses in rhesus macaques

Figure 8

The immune response to the MPER HIV-1 insert. Five out of six macaques in group 3 (A) and in group 1 (B) produced high-titered antibodies in response to the MPER insert. One animal showed a moderate response. The sera were tested four to seven weeks after immunization with replicating vectors in group 3 macaques and four weeks after live rubella vectors in group 1. The empty rubella vaccine control (CL6A) elicited no antibodies, indicating specificity for the insert. No binding to gp120 was observed in any serum, indicating antibody specificity for the MPER insert. However, the group 1 antibodies did not bind monomeric MPER peptides corresponding to the 2F5 and 4E10 epitopes, and similar results were obtained with group 3 antibodies.

Back to article page

Retrovirology

ISSN: 1742-4690

Contact us