From: Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA
Enzyme | IC50(nM) of EFdA-TP ± SD (Fold change) | Hypersusceptibility enhancement in the presence of ATP | |
---|---|---|---|
Without ATP | With 3.5 mM ATP | ||
WT RT | 186 ± 40a (1)b | 318 ± 99a (1)b | 1c |
K65R RT | 125 ± 28a (0.7)b | 131 ± 28a (0.4)b | 1.8c |