Table 1 Cellular transcription factors predicted to bind to their respective putative consensus sequences on the ERVK LTR
From: Endogenous retrovirus-K promoter: a landing strip for inflammatory transcription factors?
Transcription Factor | Consensus sequence | References |
|---|---|---|
Activating Protein 1 (AP-1); c-Jun/c-Fos | TGA(G/C)TCA | [34] |
Activating Protein 2 (AP-2α) | GCCNNNGGC | [35] |
Androgen receptor (AR) | GG(A/T)ACANNNTGTTCT (ARE) | [36] |
cAMP Response Element Binding (CREB) protein | T(G/T)ACGTCA (CRE) | [37] |
cAMP Response Element Modulator (CREM-α) | T(G/T)ACGTCA (CRE) | [37] |
CCAAT-Enhancer Binding Protein (C/EBP) | N(A/G)CCAAT | |
Cellular Myeloblastosis virus protein (c-Myb) | (T/C)AAC(G/T)G | [40] |
Cellular Myelocytomatosis virus protein (c-Myc) | NNNCACGTGNN (E-box) | |
Early B-cell Factor (EBF) | CCCNNGGG | [43] |
Estrogen Receptor (ER-α; ER-β) | GGTCANNNTGACC (ERE) | [44] |
E-twenty six (ETS-1; ETS-2) | GGA(A/T) | [45] |
ETS-like Transcription Factor 1 (Elk-1) | GGA(A/T) | [45] |
GATA binding protein (GATA) | (A/T)GATA(A/G) | [46] |
Glucocorticoid Receptor (GR-α; GR-β) | GGTACANNNTGTTC (GRE) | [47] |
Ikarose-1 (Ik-1) | TGGGA(A/T) | [48] |
Interferon Regulatory Factor (IRF-1; IRF-3; IRF-7) | GAAANN repeats (ISRE) | |
Lymphoid Enhancer-binding Factor 1 (LEF-1) | CTTTGAA | [51] |
Microphthalmia-associated Transcription Factor-M (MITF-M) | CA(C/T)GTG (E-box) | [23] |
Monocyte Enhancer Factor-2 (MEF-2A) | CT(A/T)(A/T)AAATAG | [52] |
Myc Associated Zinc finger protein (MAZ) | GGGAGGG | [53] |
Nuclear Factor of Activated T cells (NFAT-1) | GGAGAA | [54] |
Nuclear Factor I (NF-I) | TTGGCNNNNNGCCAA | [55] |
Nuclear Factor Kappa B (NF-kB) | GG(G/A)(G/A)NN(C/T)(C/T)CC | [56] |
Octamer-1 (OCT-1) | ATGCAAAT (ORE) | [57] |
Polyomavirus Enhancer Activator 3 (PEA-3) | GGA(A/T) | [45] |
Progesterone Receptor (PR-A; PR-B) | GNACANNNTGTNC (PRE) | [58] |
Protein 53 (p53) | CATTAG | [59] |
Recombination signal Binding Protein-Jk (RBP-Jk) | (C/T)GTGGGAA | [60] |
Sex-determining Region Y (SRY) | (A/T)(A/T)CAA(A/T) | [61] |
Signal Transducers and Activators of Transcription (STAT) | TTCNNNNGAA | [62] |
Specificity Protein (Sp-1; Sp-3) | GGGCGG (GC-box) | [22] |
TATA Binding Protein (TBP) | TATAAA (TATA box) | [63] |
T cell Factor 1 (TCF-1) | (G/C)ATCAAAGG | [64] |
Transcription Factor II D (TFII-D) | TATAAA (TATA box) | [63] |
Transcription Factor II I (TFII-I) | CANNTG | [65] |
Upstream Transcription Factor 1 (USF-1) | CACGTG (E-box) | [41] |
Vitamin D Receptor (VDR) | G(G/T)TCA | [66] |
X-box binding protein (XBP-1) | CCACG | [67] |
Yin Yang 1 (YY1) | GCCATNTT | [68] |