Table 1 Overview of antiretroviral compounds
Inhibitor | Target | EC50 (nM)a |
|---|---|---|
UC781 | Reverse transcriptase | 35 |
Dapivirine (TMC120) | Reverse transcriptase | 5 |
Tenofovir (TFV) | Reverse transcriptase | 4800 |
Saquinavir (SQV) | Protease | 35 |
Lopinavir (LPV) | Protease | 40 |
Raltegravir (RLT) | Integrase | 18 |
Maraviroc (MRV) | CCR5 | 88 |
Enfuvirtide (T20) | Gp41 | 35 |
C34-cholesterol (C34-chol) | Gp41 | 7.5 |
Griffithsin (GRFT) | Glycans on gp120 | 1.5 |
M48U1 | CD4 binding site on gp120 | 35 |
Soluble CD4 (sCD4) | Reverse transcriptase | 116 |