From: Cellular and molecular mechanisms involved in the establishment of HIV-1 latency
Mechanisms associated with latency | Evidence for a role in establishing latency in: | |
---|---|---|
Cell line modelsa | Primary cell modelsa | |
Transcriptional interference | Yes [97] | |
Limiting transcription factors | Yes [81] | |
Limiting P-TEFb | ?c | |
Transcriptional repressors | ? | ? |
Histone deacetylation | Yes [113] | Yes [69] |
Nod [81] | ||
Histone methylation | Yes [69] | |
DNA methylation | No [81] | ? |
Nucleosome positioning | Yes [117] | ? |
Insufficient Tat activity | Yes [69] | |
Insufficient mRNA nuclear export | ? | Yes [3] |
Insufficient mRNA splicing | ? | Yes [4] |
miRNA | ? | ? |
Homeostatic proliferation | ? | ? |