Early steps of retrovirus replicative cycle

Retrovirology

Table 1 Examples of cellular factors inhibiting early steps of retroviral cycle.

	Restricted Retroviruses^a	Step being affected^b	Viral determinant^c	Distribution	Cloned
CEM15	HIV-1	RT	Vif	human	yes
Fv1	N-MLV or B-MLV	between RT and integration	CA	Mouse	yes
Ref1	N-MLV, EIAV	between entry and RT	CA	various mammals	yes*
Lv1	N-MLV, HIV-1, HIV-2, SIVmac, EIAV	between entry and RT	CA	various mammals	yes
Lv2	HIV-2	between RT and nuclear entry	CA / Env	human	no

Abbreviations: ^a HIV-1, human immunodeficiency virus type 1 ; HIV-2, human immunodeficiency virus type 2 ; SIVmac, simian immunodeficiency virus macaques ; N-MLV, N-tropic murine leukemia virus ; B-MLV, B-tropic murine leukemia virus ; EIAV, equine infectious anemia virus. ^b RT, reverse-transcription. ^c CA, capsid protein ; Env, envelope glycoproteins. *Personal communications and unpublished data.

ISSN: 1742-4690