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Table 1 Inhibitory effects of SCH-C and AMD3100 on HIV-1 replication in U87.CD4.CXCR4 and U87.CD4.CCR5 cells.

From: Establishment of a novel CCR5 and CXCR4 expressing CD4+ cell line which is highly sensitive to HIV and suitable for high-throughput evaluation of CCR5 and CXCR4 antagonists

  

IC50a (ng/ml)

  

U87.CD4.CCR5 cells

U87.CD4.CXCR4 cells

Virus strain

Co-receptor Use

SCH-C

RANTES

LD78β

AMD3100

SDF-1

BaL

R5

58

>1000

>1000

NA

NA

NL4.3

X4

NA

NA

NA

3.6

>1000

HE

R5/X4

0.4

200

18

3.3

>1000

  1. a Effect of AMD3100 and SCH-C and the chemokines SDF-1, RANTES and LD78β on the replication of laboratory HIV-1 strains BaL, NL4.3 and HE. Virus yield was monitored by p24 HIV-1 Ag ELISA o cell-free supernatant at 4–5 days after infection. NA = Not applicable
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Retrovirology

ISSN: 1742-4690

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